Platelet-Rich Fibrin (PRF) Injections in Ottawa

Platelet-rich fibrin (PRF) is an advanced autologous biologic injection therapy derived from a patient’s own blood and used in select musculoskeletal conditions. PRF is designed to provide a sustained release of platelets, growth factors, and cellular components to support tissue healing and symptom improvement over time.

PRF injections are available following consultation with Dr. Sonam Maghera. Procedures are performed in a licensed medical facility in Ottawa. Treatment decisions are made on an individual basis after clinical assessment and imaging review.

What is Platelet-Rich Fibrin (PRF)?

Platelet-rich fibrin (PRF) is a second-generation platelet concentrate created by processing a sample of the patient’s own blood using a specialized centrifugation technique.

Unlike platelet-rich plasma (PRP), PRF forms a fibrin matrix that contains platelets, leukocytes, and growth factors. This fibrin scaffold allows for a more gradual and sustained release of biologically active components after injection.

PRF is entirely autologous and does not contain additives or anticoagulants.

PRF may be used in joints, tendons, ligaments, or soft tissue structures depending on the clinical indication.

How does PRF work?

PRF works by delivering a concentrated and structured biologic scaffold to the target tissue.

After injection into the affected area:

  • The fibrin matrix acts as a scaffold that helps localize and retain growth factors

  • Platelets and leukocytes release signaling molecules gradually over time

  • These signals may help modulate inflammation and support tissue repair

The goal is to create a biologic environment that supports healing over a longer duration compared to liquid-based platelet therapies.

Similar to PRP, PRF does not act as a pain-numbing medication. Instead, it works by influencing the body’s natural healing processes.

Symptom improvement—when it occurs—is typically gradual and may develop over weeks to months.

How long does PRF last?

For tendon and soft tissue conditions, PRF may support a more sustained healing response due to its fibrin-based structure and slower release of growth factors. When effective, benefits may persist beyond the initial recovery phase, depending on tendon health, chronicity, and rehabilitation.

For joint conditions, including osteoarthritis, PRF is primarily used for symptom modulation. Clinical studies suggest that symptom improvement, when it occurs, may last approximately 6–12 months, and repeat injections may be considered thereafter.

PRF does not reverse arthritis or regenerate joint cartilage, and outcomes vary between individuals. As with all biologic treatments, response depends on the underlying pathology, disease severity, and patient-specific factors.

Who may be a candidate for PRF?

PRF may be considered for adults with select musculoskeletal conditions, including:

  • Tendinopathy (acute or chronic), such as Achilles, patellar, gluteal, rotator cuff, or elbow tendinopathy

  • Partial tendon tears, where surgery is not indicated

  • Ligament injuries, including partial tears or chronic ligament pain

  • Bursitis that has not responded to conservative treatment

  • Mild to moderate osteoarthritis, particularly of the knee or hip

  • Cartilage injury or chondropathy, including focal cartilage defects

  • Meniscal pathology, such as degenerative or stable meniscal tears

  • Muscle injuries, including partial muscle tears or chronic myofascial pain

  • Persistent joint or soft-tissue pain despite appropriate rehabilitation and conservative management

PRF is not appropriate for every condition or every patient, and outcomes vary depending on tissue type, chronicity, severity of pathology, and overall clinical context. A medical assessment is required to determine whether PRF is a suitable option.

How is the injection performed?

PRF is prepared by drawing a sample of the patient’s blood and processing it using a specific centrifugation protocol to create a fibrin-based injectable product.

The injection is performed:

  • Under sterile conditions

  • Typically with ultrasound guidance to ensure accurate placement

  • In a licensed medical facility

Depending on the condition being treated, one or more injections may be recommended.

PRF compared with other knee injections

  • Corticosteroid injections – short-term symptom relief, anti-inflammatory

  • Hyaluronic acid injections – temporary lubrication and shock absorption (used in joints

  • PRP – biologic treatment using autologous blood products

  • PRF – fibrin-based biologic scaffold with slower, sustained release

  • Arthrosamid® – non-biologic injectable implant designed for long-term symptom relief for joints

Treatment selection depends on diagnosis, goals, prior treatments, and clinical findings.

Safety and evidence

PRF is derived from the patient’s own blood, minimizing the risk of allergic reaction. Reported side effects are typically mild and may include temporary pain, swelling, or stiffness.

Unlike PRP, no additives are used in the processing of this injection.

PRF is an evolving biologic therapy with growing clinical interest. Research is ongoing to better define optimal indications, preparation techniques, and long-term outcomes.

Platelet-Rich Fibrin injections in Ottawa

PRF injections are available following consultation with Dr. Sonam Maghera. Procedures are performed in a licensed medical facility in Ottawa. Treatment decisions are individualized based on clinical assessment, imaging findings, and available evidence.

Important note: Procedural options are discussed on an individual basis. Not all treatments are appropriate for every patient, and recommendations are based on clinical assessment, imaging findings, and available evidence.

Interested in learning more?

Patients interested in PRF injections require an in-person medical assessment to determine suitability. This allows for appropriate review of symptoms, imaging findings, medical history, and overall clinical context.

If you would like to inquire about consultation options:

Please include your full name, phone number, date of birth, and a brief summary of your condition and any recent imaging.

Please note: Email is not a secure or confidential form of communication. Do not include highly sensitive personal health information in your message. Additional details can be reviewed during your clinical appointment.

An inquiry does not guarantee eligibility for treatment.