Arthrosamid® Injections in Ottawa
Arthrosamid® is a long-acting injectable gel used in select patients with knee osteoarthritis. It is designed to integrate within the joint space and may provide longer-lasting symptom relief compared with temporary injectable treatments. Arthrosamid® injections are available following consultation with Dr. Sonam Maghera.
Procedures are performed in a licensed medical facility in Ottawa. Treatment decisions are made on an individual basis after clinical assessment and imaging review.
What is Arthrosamid®?
Arthrosamid® is a non-biologic injectable polyacrylamide hydrogel (2.5% iPAAG) used for the symptomatic treatment of knee osteoarthritis. Unlike temporary injections that are absorbed over weeks or months, Arthrosamid® is designed to integrate into the synovial membrane of the knee joint, where it can provide long-lasting symptom relief in appropriately selected patients.
It is delivered as a single intra-articular injection and is intended for patients who are seeking a non-surgical option for knee osteoarthritis.
How does Arthrosamid® work?
In knee osteoarthritis, the synovial membrane often becomes inflamed, fibrotic, and less elastic. This contributes to pain, joint swelling, reduced mobility, and progression of symptoms.
Arthrosamid® is designed to biomechanically increase synovial elasticity. After injection into the joint:
The gel disperses within the synovial fluid
It is transported into the synovial sub-intima via normal synovial transport mechanisms
Over several weeks, it becomes integrated within the synovial tissue, forming a stable scaffold that increases tissue elasticity
This change in synovial mechanics is thought to reduce pain drivers associated with osteoarthritis and support improved joint function over time.
How long does Arthrosamid® last?
Clinical studies have demonstrated statistically and clinically meaningful pain reduction following a single Arthrosamid® injection, with benefits maintained for up to five years in some patients.
Symptom improvement is typically gradual and may begin within the first few weeks, continuing to evolve over several months.
As with all osteoarthritis treatments, individual responses vary.
Who may be a candidate for Arthrosamid®?
Arthrosamid® may be considered for adults with:
Symptomatic knee osteoarthritis confirmed clinically and radiographically
Persistent pain despite conservative management
Limited or short-term benefit from corticosteroid or hyaluronic acid injections
A desire to delay or avoid knee replacement surgery
Patient selection is important. Arthrosamid® is not appropriate for every patient with knee pain or arthritis, and a consultation is required to determine suitability.
How is the injection performed?
Arthrosamid® is administered as a single intra-articular knee injection, typically using image guidance to ensure accurate placement within the joint.
The procedure is performed under sterile conditions in a licensed medical facility. If a joint effusion is present, it may be aspirated prior to injection. The total injected volume is 6 mL, delivered during one treatment session.
Arthrosamid® compared with other knee injections
There are several injectable options used for knee osteoarthritis, each with different mechanisms and expected duration of benefit:
Corticosteroid injections – typically short-term pain and inflammation relief
Hyaluronic acid (viscosupplementation) – temporary improvement in joint lubrication
Platelet-rich plasma (PRP) – biologic treatment using autologous blood products
Arthrosamid® – a non-biologic injectable implant designed for longer-lasting symptom relief
No single treatment is best for all patients. Choice depends on clinical findings, prior treatments, symptom severity, and patient goals.
Safety and evidence
Arthrosamid® has been studied for over two decades, with long-term follow-up data up to 10 years showing a favorable safety profile. Across studies, there were no signals of systemic adverse effects, allergic reactions, or implant migration, and no increase in complications during later knee replacement surgeries when required.
As with any intra-articular injection, transient pain, swelling, or stiffness may occur.
Arthrosamid® injections in Ottawa
Arthrosamid® injections are available following consultation with Dr. Sonam Maghera. Procedures are performed in a licensed medical facility in Ottawa. Treatment decisions are made on an individual basis after clinical assessment and imaging review.
Patients may travel from outside the Ottawa region for consultation and treatment when appropriate. Please contact the clinic for details.
Important note: Procedural options are discussed on an individual basis. Not all treatments are appropriate for every patient, and recommendations are based on clinical assessment, imaging findings, and available evidence.
Interested in learning more?
Patients interested in Arthrosamid® injections require an in-person medical assessment to determine suitability. This allows for appropriate review of symptoms, imaging findings, medical history, and overall clinical context.
If you would like to inquire about consultation options, please email:
Please include your full name, phone number, date of birth, and a brief summary of your condition and any recent imaging.
Please note: Email is not a secure or confidential form of communication. Do not include highly sensitive personal health information in your message. Additional details can be reviewed during your clinical appointment.
An inquiry does not guarantee eligibility for treatment.